This ultra-short introduction to TeX for Mac OS X users recommends i-Installer [download] as the installation method, and TeXShop [download] as a front-end.
So far I'm using Fink's teTeX distribution with Enhanced Carbon Emacs (which includes the AUCTeX Emacs mode). This works out of the box, including the use of Preview to view and print rendered output. I prefer this set-up because I'm using Emacs for TeX at work (and getting away with it, so far), and prefer the consistency.
Mac-TeX, a site at PennState with resources for Mac OS X TeX users, with mailing list. A LaTeX and Mac OS X FAQ.
