Does your Palm Pilot HotSync connection drop while you're syncronizing AvantGo? Apparently, it just does that. The solution is to cut down on your channels, set them to update less frequently, or just uninstall the whole damn thing. (If you need to sync the other stuff and don't want to hassle, you can temporarily set HotSync to skip AvantGo for one sync.)
What I really don't like is that it resets all of my USB devices when it does that, which gives me the willies.